Bio-informatique Computational and mathematical biology (CMB)
  • Code: S40BI1Z1
  • Language : English
  • Hourly volume : 18 hours

This course Fundamentals in biology is divided in 2 parts taught during the 1st and 2nd semester of CMB. In the first semester, we will give a presentation of the evolutionary theories that have founded modern biology (from Lamarck to Darwin), and a synthesis of the discoveries that have led to current concepts of molecular and cellular biology : the role of macromolecules in cell function (information transfer between DNA, RNA, proteins, regulation, etc.), heredity and cellular adaptation. Below are some topics covered during the lectures : Information, evolution causes for living organisms Cellular information Epigenetics – phenomenons, information, adaptation, mechanisms

This course is a quick revision of the basics of probability and statistics. The concepts will be taught in relation to concrete biology exemples (genome analysis, complex systems).

The following topics will be covered.

  • Combinatorial analysis
  • Concept of probability
  • Discrete distributions (Bernoulli, binomial, geometric, hypergeometric, Poisson)
  • Quick review of the basic continuous laws (normal and Student’s distribution)
  • Estimation and sampling
  • Statistical hypothesis tests

Some biological examples of applications could concern the probability of patterns in genomic sequences, the detection of differentially expressed genes.